2-MT-63 - CAS 870225-11-9

2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4) .

Others, Tie-2

Others, Tyrosine Kinase/Adaptors

870205

C29H30F4N8O2

598.59

O(C1=C(C=CC=N1)C=2N=C(NC)N=CN2)C3=CC(C(NC4=C(N(CCCN(C)C)C)C=CC(C(F)(F)F)=C4)=O)=C(F)C=C3

-20°C

Ice Packs

Small Compound