2-PyriMidinaMine, 4-[3-fluoro-5- (4-Morpholinyl) phenyl - CAS 1128096-64-9

2-Pyridinamine, 4-[3-fluoro-5- (4-morpholinyl) phenyl] (Compound 9l) is an ATP-competitive JNK (c-Jun N-terminal kinase) inhibitor with IC50 values of 0.099 μM and 0.148 μM for JNK1 and JNK3 respectively, exhibiting the advantage of blood-brain barrier penetration. 2-Pyridinamine, 4-[3-fluoro-5- (4-morpholinyl) phenyl] inhibits c-Jun phosphorylation and reactive oxygen species (ROS) generation, making it suitable for neurodegenerative disease research.

JNK, ROS

MAPK, Immunology/Inflammation

1128023

0.9994

C26H27FN8O2

502.54

FC1=CC(=CC(=C1)N2CCOCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5N=C(N=C5)N6CCOCC6

-20°C

Ice Packs

Small Compound