2′-Thioadenosine - CAS 136904-69-3

2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 μM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].

EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

136832

C10H13N5O3S

283.31

S[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

-20°C

Ice Packs

Small Compound