20-HEPE - CAS 116477-57-7

20-HEPE, a metabolite of eicosapentaenoic acid, is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.

Others, PPAR

Metabolism, Others, DNA Damage/DNA Repair

116413

C20H30O3

318.457

OCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

-20°C

Ice Packs

Small Compound