20S Proteasome-IN-4 - CAS 2827061-47-0

20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM against the T. b. brucei 20S proteasome, making it suitable for human African trypanosomiasis (HAT) research [1].

Others, Parasite, Proteasome

Others, Ubiquitination, Microbiology/Virology, Proteases/Proteasome

2827014

C20H18ClF2N3O3

421.83

N(C=1C2=C(N=C(C(NC[C@H](CO)OC)=O)C1)C=CC(Cl)=C2)C3=C(F)C(F)=CC=C3

-20°C

Ice Packs

Small Compound