22- (4′-py) -JA - CAS 1178895-15-2

22- (4′-py) -JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF) . Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].

Akt, mTOR

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

1178878

C32H30N4O8

598.6

C(OC(=O)C=1C=CN=CC1)[C@@H]2N3[C@]([C@]4(C5=C(C[C@@]([C@@H]3C#N)(N4C)[H])C(=O)C(C)=C(OC)C5=O)[H])(CC6=C2C(=O)C(OC)=C(C)C6=O)[H]

-20°C

Ice Packs

Small Compound