(2Z,3Z) -U0126 - CAS 218601-62-8

(2Z,3Z) -U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.

Others, MEK

MAPK, Others

218531

C18H16N6S2

380.49

C(/C(=C(/SC1=C(N)C=CC=C1)\N)/C#N)(=C(\SC2=C(N)C=CC=C2)/N)\C#N

-20°C

Ice Packs

Small Compound