3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone - CAS 125537-92-0

5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev) MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.

HIV Protease, Topoisomerase

DNA Damage/DNA Repair, Proteases/Proteasome, Microbiology/Virology

125537-92-0

C17H14O8

346.29

COc1c(O)cc(cc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1

-20°C

Ice Packs

Natural Product