3-Acetylpyridine adenine dinucleotide - CAS 86-08-8

3-Acetylpyridine adenine dinucleotide functions as an alternative reductant in glutamate-synthase-catalyzed glutamate synthesis. 3-Acetylpyridine adenine dinucleotide demonstrates kinetic parameters in the AcPdADH-dependent reaction wherein Kcat and Km values for other substrates are reduced approximately fourfold relative to the NADH-dependent reaction. 3-Acetylpyridine adenine dinucleotide shows a Km of ~3 μM and acts as a competitive inhibitor of NADH in NADH-dependent glutamate synthesis with a Ki of 1 μM. 3-Acetylpyridine adenine dinucleotide provides meaningful mechanistic insights into redox cofactor selectivity in enzymatic glutamate biosynthesis.

GluR

Neuroscience

86-08-8

0.95

C22H28N6O14P2

662.44

O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]=5C=C(C(C)=O)C=CC5)(=O)[O-])(=O)O)[C@H]1O

-20°C

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Inhibitors & Agonists