3′-Azido-2′,3′-dideoxy-CTP - CAS 92562-77-1

3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analogue containing a 3-azido group. It functions as a chain terminator when incorporated into nascent DNA strands by HIV reverse transcriptase, effectively inhibiting DNA synthesis due to the absence of a 3'-hydroxyl group, thereby blocking viral replication. The IC50 for WTHIV is 15.6 μM, and for AZTRHIV, it is 160.8 μM. This compound exhibits antiviral activity.

HIV Protease, DNA/RNA Synthesis

Proteases/Proteasome, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

92484

C9H15N6O12P3

492.17

O=C1N([C@@H]2O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](N=[N+]=[N-])C2)C=CC(N)=N1

-20°C

Ice Packs

Small Compound