3′-Azido-2′,3′-dideoxy-GTP - CAS 94059-38-8

3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki of 1.5 μM. This compound can be integrated by telomerase into the 3′ end of DNA and has the ability to inhibit telomerase activity in HeLa cells in vitro.

Telomerase

DNA Damage/DNA Repair

94013

C10H15N8O12P3

532.19

O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](N=[N+]=[N-])C3)NC(N)=N1

-20°C

Ice Packs

Small Compound