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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles - CAS 287196-91-2

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles - CAS 287196-91-2

MF-0057382-01

$1,383.80 USD
$1,383.80 USD
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Product Details

  • Bioactivity

    3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles serves as an inhibitor of both bone morphogenetic protein 2 (BMP2), with an IC50 value of 2.2 μM, and mitogen-activated protein kinase 1 (MEK1) . Additionally, this compound demonstrates anti-inflammatory and neuroprotective effects in an EAE mouse model.

  • Target

    TGF-beta/Smad, MEK

  • Related Pathways

    MAPK, Stem Cells

  • CAS Number

    287196-91-2

  • Molecular Formula

    C11H6F3N3OS

  • Molecular Weight

    285.25

  • SMILES

    N#CC=1C(=O)NSC1NC=2C=CC=CC2C(F)(F)F

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound