3-Methylthienyl-carbonyl-JNJ-7706621 - CAS 443798-09-2

3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK), showing IC50 values of 6.4 nM for CDK1/cyclin B and 2 nM for CDK2/cyclin A. It also exhibits potent inhibition of GSK-3 (IC50 = 0.041 μM) and moderate inhibition of CDK4, VEGF-R2, and FGF-R2 (IC50 = 0.11 μM, 0.13 μM, and 0.22 μM, respectively), making it significant for cancer research.

VEGFR, GSK-3, FGFR, Others, CDK

Tyrosine Kinase/Adaptors, Others, PI3K/Akt/mTOR signaling, Stem Cells, Angiogenesis, Cell Cycle/Checkpoint

443798-09-2

C14H14N6O3S2

378.43

Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N

-20°C

Ice Packs

Small Compound