3-O-Methylgallic acid - CAS 3934-84-7

3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells (IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation in the gut. It inhibits transcription factors NF-κB, AP-1, STAT-1, and OCT-1, which are known to be activated in colorectal cancer.

Apoptosis, NF-κB, Caspase, STAT, OCT, DNA/RNA Synthesis

NF-κB, Cell Cycle/Checkpoint, Stem Cells, Proteases/Proteasome, Apoptosis, JAK/STAT signaling, DNA Damage/DNA Repair, Membrane transporter/Ion channel

3843

0.9956

C8H8O5

184.15

COc1cc(cc(O)c1O)C(O)=O

-20°C

Ice Packs

Natural Product