(3S,4S) -PF-06459988 - CAS 1858291-14-1

(3S, 4S) -PF-06459988 is the less active S enantiomer of PF-06459988, a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR), exhibiting excellent selectivity against EGFR wild-type due to its minimally reactive electrophile, reducing off-target labeling likelihood.

Others, EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Others, Angiogenesis

1858276

C19H22ClN7O3

431.88

CO[C@@H]1CN(C[C@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C

-20°C

Ice Packs

Small Compound