4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid - CAS 124243-00-1

4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid (Bis-sulfone Acid) is a strong covalent linker containing a free carboxylic acid and two tosyl groups. 4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid permits sequential displacement of each tosyl group by thiol or amine nucleophiles through Michael addition. 4- (3-Tosyl-2- (tosylmethyl) propanoyl) benzoic acid enables covalent “stapling” of two reduced cysteine residues on a protein to restore disulfide bridges, while the free carboxylic acid can be transformed into amides or esters, making the molecule a versatile tool for protein engineering and bioconjugation.

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124243-00-1

0.98

C25H24O7S2

500.58

O=C(O)C1=CC=C(C=C1)C(=O)C(CS(=O)(=O)C2=CC=C(C=C2)C)CS(=O)(=O)C3=CC=C(C=C3)C

-20°C

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