4,4′-Secalonic acid D - CAS 2265910-52-7

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. By inhibiting PARP1, 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activating the caspase-3/GSDME pathway, which leads to tumor cell apoptosis (apoptosis) and pyroptosis (pyroptosis) . It exhibits antitumor activity.

Reactive Oxygen Species, PARP, Pyroptosis, Caspase, Apoptosis

Immunology/Inflammation, NF-κB, Metabolism, Apoptosis, Proteases/Proteasome, Chromatin/Epigenetic, DNA Damage/DNA Repair

2265910-52-7

C32H30O14

638.572

C(OC)(=O)[C@]12C(C(=O)C=3C(O1)=C(C=CC3O)C4=C5C(C(=O)C=6[C@@](C(OC)=O)(O5)[C@H](O)[C@@H](C)CC6O)=C(O)C=C4)=C(O)C[C@H](C)[C@H]2O

-20°C

Ice Packs

Natural Product