4,5-Dimethoxycanthin-6-one - CAS 18110-87-7

4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 μM, Ki: 2.6 μM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.

PDE, Cytochromes P450, Antibacterial

Microbiology/Virology, Metabolism

18110-87-7

0.9893

C16H12N2O3

280.28

COc1c(OC)c(=O)n2c3ccccc3c3ccnc1c23

-20°C

Ice Packs

Natural Product