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4-Br-Bnlm - CAS 1654775-71-9
4-Br-Bnlm - CAS 1654775-71-9
SKU:MF-0058393-01
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Product Details
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Bioactivity
4-Br-Bnlm, with an EC 50 of 0.96 μM, acts as a selective inhibitor of glucose-regulated protein 94 (Grp94) . It effectively reduces both mutant and wild-type misfolded myocilin proteins in cells, thereby enhancing the clearance of toxic forms of myocilin and diminishing myocilin toxicity [1] [2].
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Target
Others, HSP
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Related Pathways
Others, Cytoskeletal Signaling, Metabolism
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CAS Number
1654775-71-9
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Molecular Formula
C20H18BrClN2O4
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Molecular Weight
465.72
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SMILES
C(OC)(=O)C1=C(CCC=2N(CC3=CC=C(Br)C=C3)C=CN2)C(Cl)=C(O)C=C1O
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Small Compound