4-oxo Docosahexaenoic Acid - CAS 845673-74-7

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple-negative breast cancer cell lines [MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549] at 50-100 μM but increases the proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and dendritic cells with EC50 values of approximately 8-16 μM.

Others, PPAR

DNA Damage/DNA Repair, Others, Metabolism

845592

C22H30O3

342.479

CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C=C/C(=O)CCC(O)=O

-20°C

Ice Packs

Small Compound