4-tert-Octylphenol - CAS 140-66-9

4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), thereby diminishing the proliferation of neuronal progenitors. Consequently, 4-tert-Octylphenol adversely affects brain development and behavior in mice.

DNA/RNA Synthesis, Endogenous Metabolite, Apoptosis

Metabolism, Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

65

0.9979

C14H22O

206.32

CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1

-20°C

Ice Packs

Natural Product