4beta-Hydroxywithanolide E - CAS 54334-04-2

4beta-Hydroxywithanolide E (4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by modulating splicing factors and histone modifications.4bHWE is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity, it decreases inflammatory responses by inhibiting the NF-ÎoB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance.

PPAR, COX, PARP, NF-κB, HSP

Cytoskeletal Signaling, DNA Damage/DNA Repair, Neuroscience, Metabolism, Immunology/Inflammation, NF-κB, Chromatin/Epigenetic

54334-04-2

C28H38O8

502.604

[H][C@@]12C[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3(O)CC[C@@]4(O)[C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]3(C)C(=O)C=C[C@H](O)[C@@]13O2 |c:37,t:26|

-20°C

Ice Packs

Natural Product