(±) 5 (6) -DiHET - CAS 213382-49-1

5 (6) -DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5 (6) -EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5 (6) -EET, facilitating its measurement by utilizing the compound's conversion to 5 (6) -δ-lactone in solution. Additionally, 5 (6) -DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia.

Others

Others

213382-49-1

C20H34O4

338.5

C(C(C/C=C\C/C=C\C/C=C\CCCCC)O)(CCCC(O)=O)O

-20°C

Ice Packs

Small Compound