5α-Androstan-3β-ol - CAS 1224-92-6

5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 μM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 μM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 μM, compared to >150 μM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.

Endogenous Metabolite, Others

Others, Metabolism

1224-92-6

C19H32O

276.46

C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)CCC4)[H])(CC[C@]1(C[C@@H](O)CC2)[H])[H])[H]

-20°C

Ice Packs

Small Compound