5-Benzyloxygramine - CAS 1453-97-0

5-Benzyloxygramine is an N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. It stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization, which was further confirmed in cell studies[1]. [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63 (6) :3131-3141.

5-HT Receptor, Dopamine Receptor, Antibiotic

Microbiology/Virology, Neuroscience, GPCR/G Protein

1356

0.9913

C18H20N2O

280.36

CN(C)Cc1c[nH]c2ccc(OCc3ccccc3)cc12

-20°C

Ice Packs

Small Compound