5β-Cholestane-3α,7α,12α,25-tetrol - CAS 18866-87-0

5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 μM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.

Others, GPCR19

GPCR/G Protein, Others

18779

C27H48O4

436.67

O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCCC(C)(C)O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]4(C)[C@](C1)(C[C@H](O)CC4)[H])[H])[H])[H]

-20°C

Ice Packs

Small Compound