5-cis Carbaprostacyclin - CAS 69609-77-4

5-cis Carbaprostacyclin, a stable analog of PGI2 and an isomer of carbaprostacyclin, is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. It is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 μM compared to 5.9 μM for carbaprostacyclin and even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.

Prostaglandin Receptor, Others, PPAR

DNA Damage/DNA Repair, Others, GPCR/G Protein, Immunology/Inflammation, Metabolism

69528

C21H34O4

350.49

C(=C/[C@H](CCCCC)O)\[C@@H]1[C@@]2([C@@](C\C(=C\CCCC(O)=O)\C2)(C[C@H]1O)[H])[H]

-20°C

Ice Packs

Small Compound