5-Fluorouracil-13C,15N2 - CAS 1189423-58-2

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

HIV Protease, Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Cell Cycle/Checkpoint, Proteases/Proteasome, Apoptosis, Metabolism, Microbiology/Virology, DNA Damage/DNA Repair

1189363

C4H3FN2O2

133.057

Fc1c[15nH][13c](=O)[15nH]c1=O

-20°C

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