5-HT6 inverse agonist 1 - CAS 2727088-38-0

5-HT6 inverse agonist 1 (Compound 33) is an antagonist of the 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. This compound can inhibit 5-HT6R-mediated Cdk5 and mTOR signaling pathways and reduce tactile allodynia induced by spinal nerve ligation (SNL) in rat models.

5-HT Receptor, mTOR, CDK

Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Neuroscience, GPCR/G Protein

2727050

C22H22Cl2FN3O3S

498.4

Cl.O=C(NC1CCNCC1)C=2C=CN(C2C=3C=CC(F)=CC3)S(=O)(=O)C=4C=CC=C(Cl)C4

-20°C

Ice Packs

Small Compound