5-HT7R antagonist 3 - CAS 1887043-58-4

Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.

Dopamine Receptor, 5-HT Receptor, E1/E2/E3 Enzyme, Ligand for E3 Ligase

PROTAC, GPCR/G Protein, Ubiquitination, Neuroscience

1886981

C30H33FN4O3

516.61

C(N1CCN(C[C@H](CN2C(=O)[C@@](C)(NC2=O)C3=CC=C(F)C=C3)O)CC1)(C4=CC=CC=C4)C5=CC=CC=C5

-20°C

Ice Packs

Small Compound