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5-hydroxy Diclofenac - CAS 69002-84-2

5-hydroxy Diclofenac - CAS 69002-84-2

SKU:MF-0059808-01

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  • Bioactivity

    5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.

  • Target

    Others, Apoptosis, Drug Metabolite

  • Related Pathways

    Metabolism, Apoptosis, Others

  • CAS Number

    68916

  • Molecular Formula

    C14H11Cl2NO3

  • Molecular Weight

    312.15

  • SMILES

    OC(=O)Cc1cc(O)ccc1Nc1c(Cl)cccc1Cl

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound