5-Hydroxymethyl-2'-deoxycytidine - CAS 7226-77-9

5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine in DNA. Hydroxymethyl-2'-deoxycytidine replication fork instability is associated with the presence of poly (ADP-ribose) polymerase 1 (PARP1) on chromatin.

DNA/RNA Synthesis, PARP

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Chromatin/Epigenetic

7226-77-9

0.9995

C10H15N3O5

257.24

Nc1nc(=O)n(cc1CO)[C@H]1C[C@H](O)[C@@H](CO)O1

-20°C

Ice Packs

Natural Product