5-Hydroxypropafenone hydrochloride - CAS 86383-32-6

5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC50 of 1.5 μM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.

Others, Potassium Channel

Membrane transporter/Ion channel, Others

86345

C21H28ClNO4

393.9

Cl.O=C(C1=CC(O)=CC=C1OCC(O)CNCCC)CCC=2C=CC=CC2

-20°C

Ice Packs

Small Compound