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5-Iodo-indirubin-3'-monoxime - CAS 331467-03-9
5-Iodo-indirubin-3'-monoxime - CAS 331467-03-9
SKU:MF-0004236-01
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$310.62 USD
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Product Details
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Bioactivity
5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM) .
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Target
CDK, GSK-3
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Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells, Cell Cycle/Checkpoint
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CAS Number
331467-03-9
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Molecular Formula
C16H10IN3O2
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Molecular Weight
403.17
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SMILES
O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(I)cc12
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Storage Temperature
-20°C
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Shipping Conditions
Ice Packs
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Category
Small Compound