5- (N, N-Hexamethylene) -amiloride - CAS 1428-95-1

5- (N, N-Hexamethylene) -amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM) . It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.

TRP/TRPV Channel, Sodium Channel, Apoptosis, HIV Protease, P2X Receptor

Membrane transporter/Ion channel, Proteases/Proteasome, Apoptosis, Microbiology/Virology, Neuroscience

1332

0.8548

C12H18ClN7O

311.77

NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1

-20°C

Ice Packs

Small Compound