5 (S) -HEPE - CAS 92008-51-0

5 (S) -HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO) . This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 μM concentration. Additionally, 5 (S) -HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5 (S) -HEPE are increased in hyperlipidemia patients.

Others

Others

92008-51-0

C20H30O3

318.5

[C@@H](/C=C/C=C\C/C=C\C/C=C\C/C=C\CC)(CCCC(O)=O)O

-20°C

Ice Packs

Small Compound