6 (5H) -Phenanthridinone - CAS 1015-89-0

6 (5H) -Phenanthridinone is an inhibitor of poly (ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6 (5H) -Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6 (5H) -phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimental autoimmune encephalomyelitis (EAE) . It also decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels.

Others, PARP

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

926

C13H9NO

195.22

O=C1NC2=C(C=CC=C2)C2=C1C=CC=C2

-20°C

Ice Packs

Small Compound