6-Chloromelatonin - CAS 63762-74-3

6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.

Melatonin Receptor, Dopamine Receptor

Neuroscience, GPCR/G Protein

63762-74-3

0.9936

C13H15ClN2O2

266.72

C(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1

-20°C

Ice Packs

Small Compound