6-hydroxy Bexarotene - CAS 368451-07-4

6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXRα, RXRβ, and RXRγ, as well as to the retinoic acid receptor α (RARα) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 μM, respectively. It demonstrates selective activation of RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.

Others, Endogenous Metabolite

Metabolism, Others

368451-07-4

C24H28O3

364.485

Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CC(O)C2(C)C

-20°C

Ice Packs

Small Compound