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6-O-desmethyl Donepezil - CAS 120013-56-1

6-O-desmethyl Donepezil - CAS 120013-56-1

MF-0043199-01

$307.11 USD
$307.11 USD
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Product Details

  • Bioactivity

    6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG) .

  • Target

    Potassium Channel, Others, Drug Metabolite

  • Related Pathways

    Membrane transporter/Ion channel, Others, Metabolism

  • CAS Number

    119956

  • Molecular Formula

    C23H27NO3

  • Molecular Weight

    365.47

  • SMILES

    O=C1C2=CC(O)=C(OC)C=C2CC1CC3CCN(CC=4C=CC=CC4)CC3

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound