6β-Prostaglandin I1 - CAS 62770-50-7

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.

Prostaglandin Receptor, Others

Others, GPCR/G Protein, Immunology/Inflammation

62713

C20H34O5

354.487

[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C[C@H](CCCCC(O)=O)O2

-20°C

Ice Packs

Small Compound