7,4'-Dimethoxy-3-hydroxyflavone - CAS 13198-99-7

7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-κB, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ) -induced diabetic mouse model, 7,4'-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.

PKC, Protease-activated Receptor, ROS, NF-κB, Akt, p38 MAPK, Calcium Channel, ERK

Chromatin/Epigenetic, NF-κB, Immunology/Inflammation, Membrane transporter/Ion channel, GPCR/G Protein, Cytoskeletal Signaling, MAPK, Metabolism, PI3K/Akt/mTOR signaling

13092

C17H14O5

298.29

O=C1C(O)=C(OC2=CC(OC)=CC=C21)C=3C=CC(OC)=CC3

-20°C

Ice Packs

Small Compound