7-acetyl Paclitaxel - CAS 92950-39-5

7-acetyl Paclitaxel, serving as a microtubule depolymerization inhibitor, can prevent microtubule depolymerization caused by calcium ions at a concentration of 10 μM. Additionally, this compound significantly inhibits the growth of J774.2 macrophages (IC50 = ~60 nM) and elevates levels of nitric oxide (NO) and tumor necrosis factor (TNF) in isolated mouse peritoneal macrophages.

Microtubule Associated

Cytoskeletal Signaling

92906

C49H53NO15

895.94

O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](OC(C)=O)C[C@]1(OC2)[H])C(=O)[C@H](OC(C)=O)C=4C(C)(C)[C@](O)([C@H]3OC(=O)C5=CC=CC=C5)C[C@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C4C)[H]

-20°C

Ice Packs

Small Compound