7-Chloro-4- (piperazin-1-yl) quinoline - CAS 837-52-5

7-Chloro-4- (piperazin-1-yl) quinolone is an important scaffold in medicinal chemistry, exhibiting diverse pharmacological profiles either alone or as a hybrid with other active pharmacophores. It is a potent sirtuin inhibitor, also inhibiting serotonin uptake (IC50 of 50 μM), and demonstrates antimalarial activity on D10 and K1 strains of P. falciparum with IC50 values of 1.18 μM and 0.97 μM, respectively [1].

Sirtuin, Others, Parasite

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic, Microbiology/Virology

780

0.9972

C13H14ClN3

247.72

ClC1=CC2=NC=CC(N3CCNCC3)=C2C=C1

-20°C

Ice Packs

Small Compound