7-Chlorokynurenic acid - CAS 18000-24-3

7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.

NMDAR, iGluR, GluR

Neuroscience, Membrane transporter/Ion channel

17973

0.9972

C10H6ClNO3

223.61

OC(=O)c1cc(O)c2ccc(Cl)cc2n1

-20°C

Ice Packs

Natural Product