7-Methylguanine - CAS 578-76-7

7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, exhibiting anticancer activity. As a natural nucleic acid metabolite, it may serve as a probe for protein-DNA interactions.

Endogenous Metabolite, PARP

DNA Damage/DNA Repair, Chromatin/Epigenetic, Metabolism

495

0.9999

C6H7N5O

165.15

O=C1N=C(N)NC=2N=CN(C12)C

-20°C

Ice Packs

Natural Product