8-Aminoadenosine - CAS 3868-33-5

8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. It also obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity underscores its therapeutic potential.

DNA/RNA Synthesis, Others, Akt, Apoptosis, Autophagy, mTOR

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Others, Autophagy, Apoptosis, Cell Cycle/Checkpoint, Cytoskeletal Signaling

3830

C10H14N6O4

282.26

NC=1N(C=2C(N1)=C(N)N=CN2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

-20°C

Ice Packs

Natural Product