8-Azanebularine - CAS 38874-46-3

8-Azanebularine, a chemical compound substituting hydrogen for the C6 amino group, effectively inhibits the ADAR2 reaction at elevated concentrations (IC50=15 mM), and exhibits high-affinity binding (KD=2 nM) when incorporated into an RNA structure recognized by human ADAR2. This characteristic makes 8-Azanebularine valuable for researching the ADAR-catalyzed RNA-editing reaction.

Adenosine Deaminase, Others

Metabolism, Others

38825

C9H11N5O4

253.21

O[C@H]1[C@H](N2C=3C(N=N2)=CN=CN3)O[C@H](CO)[C@H]1O

-20°C

Ice Packs

Small Compound