9 (Z),11 (E),13 (E) -Octadecatrienoic Acid ethyl ester - CAS 42021-86-3

9 (Z),11 (E),13 (E) -Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

Others, Reactive Oxygen Species

Immunology/Inflammation, Metabolism, Others, NF-κB

42021-86-3

C20H34O2

306.49

CCCC\C=C\C=C\C=C/CCCCCCCC(=O)OCC

-20°C

Ice Packs

Small Compound