A-1155905 - CAS 2228052-37-5

A-1155905 is an MCL-1 inhibitor with anticancer activity, demonstrating a half maximal inhibitory concentration (IC50) of 33.5 Nm and a dissociation constant (Ki) of 0.58 nM. This compound selectively binds to MCL-1 and possesses sufficient affinity to disrupt the MCL-1-Bim complex in live cells. The induction of death in MCL-1-dependent cell lines by A-1155905 is reliant on caspase proteins and occurs through apoptosis.

Caspase, Apoptosis, Bcl-2 Family

Apoptosis, Proteases/Proteasome

2228010

C46H51FN6O6

802.93

O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(C(=O)C)CC5)C)C)C2N1CCN6CCOCC6)CCCOC7=CC=CC=8C(F)=CC=CC78

-20°C

Ice Packs

Small Compound